Tetradecylthioacetic acid

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

十四烷基硫代乙酸是一种在 β 位有硫取代的合成脂肪酸。这种修饰使 TTA 无法进行完全的 β-氧化，并增加了其生物活性，包括优先激活过氧化物酶体增殖物激活受体 (PPAR)，并优先激活 PPARα。

Tetradecylthioacetic acid is a synthetic fatty acid with a sulfur substitution in the β-position. This modification renders TTA unable to undergo complete β-oxidation and increases its biological activity, including activation of peroxisome proliferator activated receptors (PPARs) with preference for PPARα.(In Vivo):Mice receiving HFD supplemented with 0.75% (w/w) TTA had significantly lower body weights compared to mice fed the diet without TTA. Plasma triacylglycerol (TAG) was reduced 3-fold with TTA treatment, concurrent with increase in liver TAG. Total cholesterol was unchanged in plasma and liver. However, TTA promoted a shift in the plasma lipoprotein fractions with an increase in larger HDL particles. Histological analysis of the small intestine revealed a reduced size of lipid droplets in enterocytes of TTA treated mice, accompanied by increased mRNA expression of fatty acid transporter genes. Expression of the cholesterol efflux pump Abca1 was induced in the small intestine, but not in the liver. Scd1 displayed markedly increased mRNA and protein expression in the intestine of the TTA group.

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Metabolic Enzyme/Protease

PPAR

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2921-20-2

288.49

C16H32O2S

>98% (HPLC)

In Vitro:?DMSO : ≥ 2 mg/mL (6.93 mM)

CCCCCCCCCCCCCCSCC(O)=O

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(-20℃)

With Ice Pack

≥ 2 years